Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants

Birgit Holst, Gary Williamson

Current Opinion in Biotechnology · 2008

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Summary

This 2008 review by Holst and Williamson examines how nutrients and plant bioactive compounds are absorbed and function in human metabolism, arguing for a shift beyond measuring only antioxidant properties. The authors likely emphasise the importance of understanding bioavailability—how much of an ingested compound reaches systemic circulation—and bioefficacy—the actual health-promoting mechanisms in vivo. This perspective bridges food composition with nutritional science and human health outcomes.

Regional applicability

The review addresses fundamental principles of nutrient metabolism and phytochemical function applicable across all dietary and agricultural contexts, including United Kingdom food systems and dietary guidance. The findings are relevant to UK food composition databases, health claims regulation, and dietary recommendations.

Key measures

Bioavailability and bioefficacy of nutrients and phytochemicals; antioxidant and non-antioxidant mechanisms of action

Outcomes reported

The paper likely reviews the mechanisms by which nutrients and phytochemicals are absorbed and utilised in the body, moving beyond simple antioxidant capacity assessments.

Theme
Nutrition & health
Subject
Food composition & nutrient databases
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
System type
Food supply chain
DOI
10.1016/j.copbio.2008.03.003
Catalogue ID
SNmqx9h9gm-9ego2s

Topic tags

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