Api AM, Bartlett A, Belsito D, Botelho D, Bruze M, Bryant-Friedrich A, Burton GA, Cancellieri MA, Chon H, Cronin M, Crotty S, Dagli ML, Dekant W, Deodhar C, Farrell K, Fryer AD, Guttenberg M, Jones L, Joshi K, Lapczynski A, Laskin DL, Lavelle M, Lee I, Moustakas H, Muldoon J, Penning TM, Piersma AH, Ritacco G, Sadekar N, Schember I, Schultz TW, Siddiqi F, Sipes IG, Sullivan G, Thakkar Y.

doi:10.1016/j.fct.2026.116399

Summary

This paper presents an updated safety assessment of terpinyl isobutyrate, a volatile organic compound commonly used as a fragrance ingredient in food flavourings and consumer products. The Research Institute for Fragrance Materials (RIFM) Expert Panel evaluated available toxicological data to establish safety thresholds and acceptable use levels. The assessment informs regulatory guidance on permissible concentrations in food and cosmetic applications.

Regional applicability

RIFM assessments inform fragrance ingredient safety globally, including within the United Kingdom and European regulatory frameworks (EFSA, CLP Regulation). Findings are applicable to UK food safety authorities and industry compliance with fragrance ingredient regulations.

Key measures

Hazard characterisation; safety assessment; acceptable concentration limits for fragrance ingredient

Outcomes reported

Updated safety assessment of terpinyl isobutyrate, a fragrance ingredient used in food and consumer products, based on toxicological evaluation.

Theme: Measurement & metrics
Subject: Pesticides, contaminants & food safety
Study type: Systematic Review
Study design: Systematic review
Source type: Peer-reviewed study
Status: Published
System type: Laboratory / in vitro
DOI: 10.1016/j.fct.2026.116399
Catalogue ID: NRmucmlmez-003

Topic tags

fragrance ingredient safety assessment food additive terpene compound toxicology regulatory guidance

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Update to RIFM fragrance ingredient safety assessment, terpinyl isobutyrate, CAS Registry Number 7774-65-4.