Summary
This Nature Reviews Immunology paper, authored by a multidisciplinary international consortium, provides a comprehensive synthesis of neuroinflammation in Alzheimer's disease. The review examines how activation of microglia, astrocytes and other immune cells drives neurodegeneration through cytokine-mediated pathways and interactions with amyloid and tau pathology. The authors integrate emerging evidence from neuroimaging, fluid biomarkers and postmortem studies to highlight neuroinflammation as a central and potentially targetable mechanism in Alzheimer's disease aetiology.
Regional applicability
The mechanistic insights and biomarker evidence presented are directly applicable to UK clinical research and dementia diagnosis protocols. UK-based clinicians and researchers may use this synthesis to inform patient stratification, therapeutic development and the integration of neuroinflammatory biomarkers into memory clinic assessment.
Key measures
Biomarkers of neuroinflammation (including glial activation markers, cytokine profiles, phosphorylated tau, amyloid-β); neuroimaging evidence of inflammation; postmortem neuropathology; cerebrospinal fluid and blood biomarkers
Outcomes reported
This comprehensive review synthesises current understanding of neuroinflammation as a central driver of Alzheimer's disease pathology, examining immune cell activation, cytokine signalling, and glial dysfunction. The paper integrates evidence on how neuroinflammatory cascades interact with amyloid-β and tau pathology to promote neurodegeneration.
Topic tags
Dig deeper with Pulse AI.
Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.