Summary
This 2021 Nature Neuroscience study presents a genomic and proteomic atlas integrating protein expression data from brain tissue, cerebrospinal fluid, and plasma samples. By linking protein abundance to genetic variation and neurological disease associations, the research identifies proteins implicated in neurological disorders and their distribution across these compartments. The work provides as suggested by the title a resource for prioritising candidate proteins for biomarker development and therapeutic intervention in neurological disease.
Regional applicability
The proteomic resource and methodology are applicable to UK research on neurological disorders and may inform biomarker strategies in NHS neurology services, though the study cohort composition and generalisability to UK populations would require assessment.
Key measures
Protein abundance quantification in brain, CSF and plasma samples; genetic associations with neurological disorders; cross-compartment protein correlation analysis
Outcomes reported
The study created a comprehensive genomic atlas identifying proteins present in brain tissue, cerebrospinal fluid, and plasma, with prioritisation of those implicated in neurological disorders. The research mapped protein abundance and localisation across these three compartments to identify biomarkers and therapeutic targets for neurological disease.
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