Summary
This 2024 review by Sarraju and Nissen in Nature Reviews Cardiology synthesises clinical evidence on strategies for stabilising atherosclerotic plaques and, where possible, achieving regression. The paper appears to examine both pharmacological interventions and lifestyle factors—potentially including diet—relevant to plaque modification and cardiovascular risk reduction. As a clinical cardiology review, it addresses mechanisms of plaque progression and stabilisation in established atherosclerotic disease.
Regional applicability
The evidence reviewed is directly applicable to UK clinical practice and cardiovascular disease management guidelines. UK cardiologists and primary care practitioners managing atherosclerotic disease may reference this synthesis for evidence-based approaches to plaque stabilisation and risk reduction.
Key measures
Plaque composition, plaque burden, intima-media thickness, coronary artery disease progression, clinical cardiovascular events
Outcomes reported
The study reviews clinical evidence on mechanisms and interventions for atherosclerotic plaque stabilisation and potential regression in cardiovascular disease. It synthesises evidence on pharmacological and lifestyle approaches to plaque modification.
Topic tags
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