Summary
This Nature Reviews Genetics article by Wu, Eckhardt, and Baccarelli synthesises current understanding of the molecular mechanisms through which environmental exposures trigger or modulate human disease risk. The review examines epigenetic pathways—including DNA methylation and chromatin remodelling—as key mediators between exposure and phenotype. As suggested by the journal and publication year, the paper likely integrates recent advances in environmental epigenomics and systems toxicology relevant to precision public health.
Regional applicability
The mechanistic framework presented may inform UK environmental health policy and occupational exposure standards, though the review's focus on molecular pathways rather than specific UK exposure contexts or farming practices limits direct applicability to agricultural policy or food systems research.
Key measures
DNA methylation, histone modifications, chromatin remodelling, gene expression changes, environmental exposure biomarkers
Outcomes reported
The paper reviews molecular mechanisms by which environmental exposures (chemical, physical, biological) alter gene expression and epigenetic marks, ultimately contributing to human disease development. It synthesises evidence on how these pathways operate at cellular and systemic levels.
Topic tags
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