Summary
This 2024 Nature Reviews Genetics article surveys the evolution and current applications of toxicogenomics in characterising how chemical exposures affect gene expression and phenotypic outcomes. As suggested by the title and journal scope, the review examines how genomic tools enhance understanding of toxic mechanisms and support more rapid, mechanistically-informed human health risk assessment. The field represents a shift from traditional toxicology towards molecular and systems-level approaches to predict adverse health effects.
Regional applicability
Toxicogenomic methods and frameworks discussed are applicable to UK regulatory contexts, including chemical safety assessment under REACH and pesticide residue evaluation. However, adoption and integration into UK and devolved regulatory guidance remain dependent on institutional capacity and harmonisation with European and international standards.
Key measures
Gene expression profiles, genomic biomarkers, toxicological endpoints, predictive modelling approaches in toxicogenomics
Outcomes reported
The paper reviews progress in toxicogenomics — the application of genomic and transcriptomic approaches to predict toxic responses — and its role in protecting human health through improved hazard identification and risk assessment.
Topic tags
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