Summary
This meta-analysis synthesises differential gene expression data from 2,114 human postmortem brain samples to construct a consensus transcriptome atlas of Alzheimer's disease across seven brain regions. By cross-referencing 30 identified coexpression modules with 251 differentially expressed gene sets from mouse models of AD and related neurodegenerative diseases, the authors establish transcriptional correspondences that distinguish responses to amyloid versus tau pathology and reveal age- and sex-dependent disease progression signatures. The resource provides a validated framework for preclinical AD studies using mouse models.
Regional applicability
This is a molecular neuroscience study conducted in the United States with no direct applicability to United Kingdom farming systems, soils, or agricultural practice. The findings are relevant to UK-based neuroscience and pharmaceutical research communities investigating Alzheimer's disease mechanisms and translational pathways, but sit outside Vitagri's Pulse Brain's primary remit of farming systems and soil health.
Key measures
Differential gene expression patterns; coexpression modules; human-mouse transcriptional overlap; brain region-specific and pathology-specific expression signatures; age- and sex-dependent expression patterns
Outcomes reported
The study identified 30 brain coexpression modules from seven brain regions as major sources of transcriptional perturbation in Alzheimer's disease, based on meta-analysis of 2,114 postmortem samples. It characterised human-mouse transcriptional overlaps for amyloid versus tau pathology responses and identified age- and sex-dependent expression signatures.
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