Pulse Brain · Growing Health Evidence Index
Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

Global, regional, and national burden of Chagas disease, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Ewerton Cousin, Bruno Ramos Nascimento, Joanna L Whisnant, Stephanie R M Zimsen, Ashley Harris, Ísis Eloah Machado, Francisco Rogerlândio Martins‐Melo, Caroline Demacq, Pablo Perel, Yvonne Geissbühler, Madineh Abbasi, Reda Abdel‐Hameed, Jeza Muhamad Abdul Aziz, Armita Abedi, Dmitry Abramov, Eman Abu-Gharbieh, Oyelola A. Adegboye, Muhammad U. Afzal, Saira Afzal, Sajjad Ahmad, Ayman Ahmed, Karolina Akinosoglou, Salah Al Awaidy, Syed Shujait Ali, Joseph Uy Almazan, Najim Z. Alshahrani, Nelson J Alvis-Zakzuk, Saeid Anvari, Juan Pablo Arab, Jalal Arabloo, Aleksandr Y Aravkin A, Demelash Areda, Brhane Berhe Aregawi, Abdulfatai Aremu, Seyyed Shamsadin Athari, Giridhara R. Babu, Ovidiu Constantin Baltatu, Maciej Banach, Hiba Jawdat Barqawi, Mohammad‐Mahdi Bastan, Jina Behjati, Melesse Belayneh, Apostolos Beloukas, Sonu Bhaskar, Priyadarshini Bhattacharjee, Sri Harsha Boppana, Н. И. Брико, Yasser Bustanji, Mariângela Carneiro, Félix Carvalho, Muthia Cenderadewi, Vijay Kumar Chattu, Anis Ahmad Chaudhary, Patrick R Ching, Claudia Cosma, Omid Dadras, Xiaochen Dai, Samuel Demissie Darcho, Devananda Devegowda, Daniel Díaz, Paulo Magno Martins Dourado, Oyewole Christopher Durojaiye, Abdel Rahman E’mar, Abdelaziz Ed‐Dra, Ferry Efendi, Temitope Cyrus Ekundayo, Muhammed Elhadi, Mohammed Elshaer, Adeniyi Francis Fagbamigbe, Masoud Foroutan, Richard C. Franklin, Blima Fux, Rupesh K. Gautam, Miglas Welay Gebregergis, Sailaja Ghimire, Himanshu Gupta, Ahmed I Hasaballah, Kareem Hatam‐Nahavandi, Simon I Hay, Jiawei He, Olayinka Stephen Ilesanmi, Irena Ilić, Milena Ilić, Mihajlo Jakovljević, Mahsa Jalili, Nitin Joseph, Kehinde Kazeem Kanmodi, Khaled Khatab, KM Shivakumar, Mukhtar Kulimbet, Ville Kytö, Le Huu Nhat Minh, Thao T. Le, Seung Won Lee, Stephen S Lim, Yosef Manla, Bernardo Alfonso Martínez-Guerra, Tesfahun Mekene Meto, Hadush Negash Meles, Tomislav Mestrovic

The Lancet Infectious Diseases · 2025

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Summary

This Global Burden of Disease Study 2023 provides a comprehensive systematic quantification of Chagas disease burden globally, regionally, and nationally from 1990 to 2023. As suggested by the scope of the Global Burden of Disease framework, the analysis synthesises epidemiological data to establish contemporary burden distribution patterns and identify temporal trends across three decades. The findings are intended to support disease control prioritisation and evidence-based resource allocation for Chagas disease management.

Regional applicability

Whilst Chagas disease is endemic primarily in the Americas, the UK may encounter cases through immigration and travel from endemic regions. The global burden assessment provides epidemiological context for disease surveillance and clinical awareness in United Kingdom healthcare settings, though direct application is limited given the disease's low domestic prevalence.

Key measures

Incidence, prevalence, mortality rates, disability-adjusted life years (DALYs), age-standardised rates by region and country

Outcomes reported

The study quantified global, regional, and national burden of Chagas disease including incidence, prevalence, mortality, and disability-adjusted life years (DALYs) across 34 years. The analysis tracked temporal trends and geographical distribution to inform disease control priorities.

Theme
Measurement & metrics
Subject
Measurement methods & nutrient profiling
Study type
Systematic Review
Study design
Systematic analysis
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Other
DOI
10.1016/s1473-3099(25)00562-6
Catalogue ID
SNmpdjw9yi-6tcnli

Topic tags

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