Pulse Brain · Growing Health Evidence Index
Tier 1 — Meta-analysis / systematic reviewPeer-reviewed

Global burden of lower respiratory infections and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023

Sarah Brooke Sirota, Rose Bender, Regina-Mae Villanueva Dominguez, Amanda Movo, Lucien R Swetschinski, Daniel T Araki, Chieh Han, Eve E Wool, Jiawei He, Austin Carter, Ahmed Aj. Jabbar, Mohammad Amin Aalipour, Hasan Aalruz, Zahra Abbasi Dolatabadi, Hedayat Abbastabar, Samar Abd ElHafeez, Ashraf N. Abdalla, Mohammed Abdalla, Jafri Malin Abdullah, Emad M. Abdallah, Nadin M.I. Abdel Razeq, Atef Abdelkader, Sherief Abd‐Elsalam, Siddig İbrahim Abdelwahab, Meriem Abdoun, Arman Abdous, Mostafa M. Abdrabou, Jeza Muhamad Abdul Aziz, Deldar Morad Abdulah, Auwal Abdullahi, Toufik Abdul‐Rahman, Kulmira Abdykerimova, Habtamu Abebe, Armita Abedi, Asrat Agalu Abejew, Syed Hani Abidi, Olifan Zewdie Abil, Olumide Abiodun, Richard Gyan Aboagye, Hassan Abolhassani, Ulric Sena Abonie, Abdullahi Tunde Aborode, Nagah M Abourashed, Dariush Abtahi, Zhanar Abu, Rana Abu Farha, Fuad H. Abuadas, Aminu Kende Abubakar, Usman Abubakar, Nermeen M. Abu‐Elala, Eman Abu-Gharbieh, Ahmad Y. Abuhelwa, Hana J Abukhadijah, Dina Abushanab, Anirudh B. Acharya, Krishna Prasad Acharya, Swetha Acharya, Meshack Achore, Ousman Adal, Lisa C. Adams, Isaac Yeboah Addo, Tajudeen Adewumi Adebisi, David Adedia, Kamoru A. Adedokun, Nurudeen A. Adegoke, Victor Adekanmbi, Olumide Thomas Adeleke, Miracle Ayomikun Adesina, Ridwan Olamilekan Adesola, Charles Oluwaseun Adetunji, Juliana Bunmi Adetunji, Idowu Peter Adewumi, Mache Tsadik, Ripon Kumar Adhikary, Atman Adiba, Usha Adiga, Mohammad Adnan, Qorinah Estiningtyas Sakilah Adnani, Giuseppina Affinito, Saira Afzal, Gizachew Beykaso Agafari, Navidha Aggarwal, Percival Delali Agordoh, Anurag Agrawal, Williams Agyemang‐Duah, Mahsa Ahadi, Bright Opoku Ahinkorah, A. Ahmad, Aqeel Ahmad, Danish Ahmad, Faisal Ahmad, Ijaz Ahmad, Khurshid Ahmad, Muayyad Ahmad, Rabbiya Ahmad, Sajjad Ahmad, Tauseef Ahmad, Ali Ahmadi, Mahnaz Ahmadi, Ali Ahmed

The Lancet Infectious Diseases · 2025

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Summary

This Global Burden of Disease Study 2023 presents a comprehensive systematic analysis of lower respiratory infection epidemiology and aetiology across all countries from 1990 to 2023. The work synthesises data to quantify disease burden temporally and geographically, identifies major causative pathogens, and documents shifts in infection patterns over three decades. The findings are designed to support clinical practice, public health priority-setting, and resource allocation for LRI prevention and management globally.

Regional applicability

As a global analysis spanning all countries including the United Kingdom, findings provide UK-contextualised burden estimates and pathogen distribution data relevant to national public health surveillance and healthcare planning. However, the synthesis aggregates diverse epidemiological contexts; UK-specific burden trends and aetiology patterns may be detailed within the broader dataset.

Key measures

Incidence, prevalence, mortality, disability-adjusted life years (DALYs), and aetiology (causative pathogens) of lower respiratory infections by geography and time period

Outcomes reported

The study quantifies the global burden of lower respiratory infections (LRIs) across all countries from 1990 to 2023, documenting disease incidence, prevalence, mortality, and disability-adjusted life years. It identifies major causative pathogens and documents temporal and geographical shifts in infection patterns.

Theme
Measurement & metrics
Subject
Measurement methods & nutrient profiling
Study type
Systematic Review
Study design
Systematic analysis / Meta-analysis
Source type
Peer-reviewed study
Status
Published
Geography
Global
System type
Other
DOI
10.1016/s1473-3099(25)00689-9
Catalogue ID
SNmpdjw9yi-n70uyn

Topic tags

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