Summary
This review synthesises research on newborn immunity and postnatal adaptation to environmental exposures, particularly the establishment of immune-microbe mutualism. Brodin proposes that mismatches between ancestral early-life environments and modern industrialised conditions lead to dysregulation of immune-microbe interactions, contributing to rising incidences of allergies and autoimmunity. The paper integrates evidence on maternal antibody transfer, commensal microbiota development, and environmental factors shaping lifelong immune homeostasis.
Regional applicability
The review's observations on rising immune-mediated disease incidence in industrialised nations are directly relevant to United Kingdom epidemiology and public health. The framework linking environmental mismatch to immune dysregulation has implications for early-childhood interventions and dietary/environmental exposures in UK settings, though the review itself does not present UK-specific data.
Key measures
Immune development trajectories; microbiome composition and function; prevalence of allergies and autoimmune diseases in industrialised nations
Outcomes reported
The review examines how early-life immune-microbe mutualism develops and how perturbations thereof contribute to immune-mediated diseases. It proposes that environmental mismatches between ancestral and modern conditions explain dysregulation of immune-microbe interactions.
Topic tags
Dig deeper with Pulse AI.
Pulse AI has read the whole catalogue. Ask about this record, its theme, or how the findings apply to UK farming and policy — every answer cites the underlying studies.