Summary
This narrative review synthesises evidence on the role of α7 nicotinic acetylcholine receptors (α7nAChRs) in mediating nicotine's effects on airways and the development of asthma and other lung diseases. The authors integrate current mechanistic understanding of how nicotine from smoking and vaping products impacts different airway cell populations and propose potential therapeutic approaches to mitigate these effects on respiratory health.
Regional applicability
The review is globally scoped and addresses smoking and vaping—both prevalent public health concerns in the United Kingdom. Findings on nicotine-induced airway mechanisms are directly applicable to UK respiratory disease management and policy around tobacco and nicotine product regulation.
Key measures
Mechanisms of α7nAChR signalling in airway pathology; nicotine effects on airway cell types; smoking and vaping impacts on respiratory health
Outcomes reported
Review integrating current knowledge on nicotine and α7 nicotinic acetylcholine receptors in asthma and airway disease; identification of mechanisms by which nicotine impacts different airway cell types.
Topic tags
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