Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryBook chapter

Astrocytes and microglia in multiple sclerosis and neuromyelitis optica

Lin‐Jie Zhang, Alexei Verkhratsky, Fu‐Dong Shi

Handbook of clinical neurology · 2025

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Summary

This 2025 handbook chapter synthesises current understanding of astrocyte and microglial dysfunction in demyelinating neuroinflammatory diseases, particularly multiple sclerosis and neuromyelitis optica spectrum disorder. As a reference work rather than primary research, it contextualises glial pathology mechanisms for clinical and neuroscience audiences. Specific empirical findings and quantitative outcomes cannot be confirmed without access to the full text.

Regional applicability

Not applicable. This is a clinical neurology reference work addressing fundamental mechanisms of demyelinating disease pathology, without geographic specificity or agricultural/food system content.

Key measures

Not applicable — handbook chapter synthesising existing literature on glial cell pathology mechanisms

Outcomes reported

This handbook chapter synthesises current understanding of astrocyte and microglial dysfunction mechanisms in multiple sclerosis and neuromyelitis optica spectrum disorder. As a reference work, it contextualises glial pathology for clinical and neuroscience audiences rather than reporting primary empirical findings.

Theme
General food systems / other
Subject
Out of scope / non-food
Study type
Narrative Review
Study design
Narrative review
Source type
Book chapter
Status
Published
System type
Other
DOI
10.1016/b978-0-443-19102-2.00001-6
Catalogue ID
SNmq64coy2-z62mpg

Topic tags

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