Summary
This narrative review examines human in vitro models, particularly induced pluripotent stem cell-derived microglia systems, as tools for understanding chronic multiple sclerosis progression. The authors argue that these models offer advantages over animal systems for dissecting the complex cellular mechanisms driving progressive MS, with a focus on microglia's role in neuroinflammation and neurodegeneration. The review synthesises current methodological approaches, discusses their utility for target identification, and proposes a framework for therapeutic development.
Regional applicability
This is a methodological and translational review with no geographical restrictions on applicability. The advances in human in vitro model systems described are relevant internationally, including to United Kingdom neuroscience and MS research institutions and pharmaceutical development.
Key measures
Methodological assessment of induced pluripotent stem cell-based microglia models; evaluation of target identification and therapeutic engagement approaches
Outcomes reported
The review examines advances in human induced pluripotent stem cell-derived microglia models for understanding MS progression mechanisms and identifying novel therapeutic targets. It discusses the strengths, limitations, and translational applications of these in vitro systems for modulating microglia-associated neuroinflammation and neurodegeneration.
Topic tags
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