Summary
This narrative review synthesises the emerging evidence for microRNAs (miRNAs) as diagnostic and therapeutic targets in cardiovascular disease, particularly acute coronary syndrome. The authors discuss recent advances in miRNA recognition and characterisation, evaluate their potential for clinical translation either alone or combined with established biomarkers, and address current challenges and future perspectives for clinical application. The review reflects that whilst miRNA-based approaches remain experimental, they hold considerable promise for improving early diagnosis and conventional pharmacotherapy in cardiovascular disease.
Regional applicability
The review is not geographically specific and addresses general principles of miRNA biology and cardiovascular diagnostics applicable across healthcare systems. Findings would be relevant to United Kingdom cardiovascular medicine and diagnostic practice if miRNA biomarkers are adopted into routine clinical pathways.
Key measures
miRNA discovery, characterisation, diagnostic potential, therapeutic applications in cardiovascular disease, acute coronary syndrome presentation
Outcomes reported
The review examines the current understanding of microRNAs as possible targets for diagnosis and treatment in the cardiovascular system, with focus on clinical translation of miRNA-based approaches for acute coronary syndrome and other presentations.
Topic tags
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