Summary
This narrative review synthesises evidence on inflammasome activation in neurodegenerative diseases, particularly through canonical pathways triggered by accumulation of misfolded proteins such as beta-amyloid and alpha-synuclein. The authors argue that inflammasome-mediated release of pro-inflammatory cytokines (IL-1β and IL-18) and induction of pyroptosis exacerbate neuroinflammation and disease progression, making inflammasomes viable therapeutic targets for neurodegenerative disease intervention.
Regional applicability
The review is mechanistic and disease-focused rather than agriculture or food-systems centred, and thus has limited direct application to United Kingdom farming or soil health policy. However, findings on dietary or agricultural factors modulating inflammasome activation in these diseases would be transferable if discussed.
Key measures
Inflammasome activation pathways; interleukin (IL)-1β and IL-18 release; pyroptosis; misfolded protein accumulation (beta-amyloid, alpha-synuclein); neuroinflammation markers
Outcomes reported
The review examines inflammasome activation through canonical pathways in neurodegenerative diseases, particularly focusing on how misfolded proteins trigger innate immune responses. It identifies inflammasomes as potential therapeutic targets for neurodegenerative disease treatment.
Topic tags
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