Animal species in which N-nitroso compounds induce cancer

Summary

This 1981 review systematically documents the breadth of animal species in which N-nitroso compounds (NC) induce cancer, correcting what the authors identify as an understatement in prior literature. The authors present tumour induction data across 39 animal species spanning five classes, 17 orders, and 25 families, with tabulated carcinogenic effects of eight specific NC. The work provides a comprehensive taxonomic and comparative summary of NC carcinogenicity across diverse animal models.

Regional applicability

This is a fundamental laboratory and toxicology review with no geographic specificity. Its findings are applicable globally to food safety and contamination risk assessment frameworks, including those in the United Kingdom, where N-nitroso compound formation in processed and preserved foods remains a regulatory concern.

Key measures

Number of animal species susceptible to N-nitroso compound-induced tumours; taxonomic classification of susceptible species; carcinogenic potency of eight N-nitroso compounds across species

Outcomes reported

Comprehensive catalogue of animal species in which N-nitroso compounds induce tumours, covering 39 species across multiple taxonomic classes. Tabulation of carcinogenic effects of eight N-nitroso compounds across different animal models.

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