Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

Polyphenols and metabolism: from present knowledge to future challenges.

Quesada-Vázquez S, Eseberri I, Les F, Pérez-Matute P, Herranz-López M, Atgié C, Lopez-Yus M, Aranaz P, Oteo JA, Escoté X, Lorente-Cebrian S, Roche E, Courtois A, López V, Portillo MP, Milagro FI, Carpéné C.

J Physiol Biochem · 2024

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Summary

This narrative review synthesises current evidence on polyphenol metabolism in humans, examining how these plant compounds are absorbed, metabolised, and exert physiological effects. The authors identify key knowledge gaps and methodological challenges in studying polyphenol bioavailability and health impact, proposing directions for future research to bridge the gap between intake and demonstrated health benefits.

Regional applicability

The findings on polyphenol metabolism are applicable to UK dietary recommendations and food fortification strategies, particularly regarding intake targets for foods rich in polyphenols such as fruits, vegetables, and whole grains. UK nutritional policy and public health guidance could benefit from clearer evidence on optimal polyphenol intake thresholds.

Key measures

Polyphenol bioavailability, metabolic pathways, absorption rates, health outcomes associated with polyphenol intake

Outcomes reported

The study reviewed current knowledge on polyphenol metabolism and bioavailability, examining their physiological effects on human health outcomes. It identified gaps and future research challenges in understanding how dietary polyphenols are processed and utilised by the body.

Theme
Nutrition & health
Subject
Phytochemicals & bioactive compounds
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1007/s13105-024-01046-7
Catalogue ID
NRmo9zxr64-08d

Topic tags

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