Summary
This narrative review synthesises current understanding of the PGC-1 coactivator family as central regulators of cellular metabolism and mitochondrial homeostasis. The authors examine mechanisms by which these proteins influence physiological processes and contribute to pathophysiological states including metabolic, cardiovascular, and neurological diseases, providing a framework for understanding their therapeutic potential.
UK applicability
The review's mechanistic insights into metabolic regulation and mitochondrial function are applicable to UK clinical practice and public health policy, particularly regarding prevention and management of metabolic and chronic degenerative diseases. Findings may inform nutritional and lifestyle interventions targeting PGC-1 regulation.
Key measures
PGC-1 family protein expression, mitochondrial biogenesis markers, metabolic parameters, disease-associated outcomes across multiple organ systems
Outcomes reported
The paper reviews the roles of the PGC-1 coactivator family (PGC-1α, PGC-1β, PGC-1-related coactivator) across physiological processes and pathophysiological conditions. It synthesises evidence on mechanisms linking these coactivators to metabolic regulation, mitochondrial function, and disease aetiology.
Topic tags
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