Summary
This randomized controlled trial in Jordan examined whether combined oral supplementation with vitamin D3 (50,000 IU weekly) and omega-3 fatty acid (300 mg daily) could improve cardiovascular risk markers in vitamin D-deficient adults. Combined treatment significantly reduced oxidised LDL-cholesterol levels (from 69.29 to 52.81 pg/mL) whilst paradoxically increasing non-HDL-C (from 118.99 to 155.26 mg/dL); neither supplement alone produced significant reductions in oxidised LDL. The authors conclude that the reduction in oxidised LDL may offset the hyperlipidaemic effect, though this finding warrants careful interpretation.
Regional applicability
This study was conducted in Jordan and may have limited direct transferability to United Kingdom populations, which have different baseline vitamin D status, dietary patterns, and genetic profiles. The findings on combined supplementation in vitamin D-deficient populations could be relevant to UK subpopulations with vitamin D deficiency (e.g. older adults, certain ethnic minorities), though UK dietary patterns and supplementation practices differ substantially.
Key measures
Oxidized LDL-C (pg/mL), non-HDL-C (mg/dL), serum LDL-C levels; supplementation dosages: vitamin D3 50,000 IU weekly, omega-3 300 mg daily, 8-week intervention period
Outcomes reported
The study measured oxidized LDL-C (Ox-LDL-C) and non-HDL-C levels in participants with vitamin D deficiency after 8 weeks of combined omega-3 and vitamin D3 supplementation. Combined treatment significantly decreased Ox-LDL-C levels and increased non-HDL-C levels.
Topic tags
Dig deeper with Pulse AI.
Ask about this record, its theme or its relevance to UK farming and policy. Pulse AI uses selected catalogue evidence and cites the sources it draws on.