Summary
This in vitro study isolated six bioactive compounds from Adhatoda vasica and Calotropis procera leaves and seeds, and evaluated their capacity to inhibit enzymes implicated in skin ageing and dysfunction. Both plant extracts demonstrated notable inhibition of tyrosinase, collagenase, elastase, and hyaluronidase, alongside antioxidant activity; electron microscopy revealed concentration-dependent morphological changes in dermal fibroblasts, suggesting potential for topical dermatological formulations.
Regional applicability
This research is conducted in vitro and does not directly address United Kingdom farming, soil health, or food systems. The plant species studied (Adhatoda vasica and Calotropis procera) are not widely cultivated in the United Kingdom and the application is cosmetic/dermatological rather than nutritional, making direct transferability to UK agricultural or dietary contexts limited.
Key measures
Tyrosinase inhibition (IC₅₀ values in µg/mL), collagenase inhibition, elastase inhibition, hyaluronidase inhibition, antioxidant activity, cytotoxicity (LDH release assay), ultrastructural morphology (SEM and TEM)
Outcomes reported
The study isolated and characterized bioactive compounds from two plant species and evaluated their inhibitory effects on skin-damaging enzymes (tyrosinase, collagenase, elastase, hyaluronidase) and antioxidant activity using in vitro assays. Ultrastructural changes in dermal fibroblasts were assessed using electron microscopy.
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