Summary
This narrative review synthesises current understanding of the bidirectional relationship between B vitamins and gut microbiota. The authors present evidence that adequate B vitamin intake maintains microbial balance and supports intestinal barrier function, whilst insufficient or excessive intake disrupts the microbiota; conversely, dysbiosis can compromise B vitamin synthesis and status. The review highlights that whilst the mechanistic underpinnings remain incompletely characterised, B vitamin status and microbiota health are interdependent factors in overall metabolic and immune function.
Regional applicability
The review addresses fundamental human nutritional physiology and microbiota interactions applicable to United Kingdom populations. Findings regarding adequate B vitamin intake recommendations and microbiota-mediated vitamin synthesis are relevant to UK dietary guidance and clinical practice, though implementation would depend on localised epidemiology of B vitamin deficiency and dysbiosis.
Key measures
Gut microbiota composition and function in relation to B vitamin intake; mechanisms of B vitamin-microbiota interaction; effects of B vitamin sufficiency/deficiency on pathogenic bacteria growth and intestinal barrier function
Outcomes reported
The review examines the bidirectional relationship between B vitamin intake and gut microbiota composition, including mechanisms by which adequate or inadequate B vitamin levels alter microbial balance and how dysbiosis affects B vitamin status.
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