Summary
This systematic review synthesises recent evidence on the therapeutic potential of silver nanoparticles in wound healing, examining their mechanisms of action across in vitro, in vivo, and clinical studies. The authors highlight that AgNPs exhibit multiple biological properties—including antibacterial, anti-inflammatory, antioxidant, and cell proliferation-promoting effects—and can be formulated into diverse delivery systems such as hydrogels, ointments, and sprays. The review emphasises that green synthesis methods are emerging as environmentally preferable approaches for producing biocompatible AgNPs whilst maintaining therapeutic efficacy.
Regional applicability
Findings on AgNP wound healing mechanisms and formulations could inform UK wound care practice and product development, particularly for managing burns, surgical wounds, and diabetic ulcers. However, direct applicability requires evaluation of UK regulatory pathways for nanomaterial-based therapeutics and confirmation of safety profiles in NHS clinical settings.
Key measures
Antibacterial efficacy, anti-inflammatory activity, antioxidant capacity, cell proliferation rates, tissue regeneration, infection risk reduction, particle size, particle shape, surface chemistry, biocompatibility, toxicity profile
Outcomes reported
The review evaluated in vitro, in vivo, and clinical studies on silver nanoparticles (AgNPs) for treating various wound types including burns, surgical wounds, and diabetic ulcers. It assessed how physicochemical properties and synthesis methods influence the biological activity and safety profile of AgNPs in wound healing applications.
Topic tags
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