Pulse Brain · Growing Health Evidence Index
Peer-reviewed

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

Bingxin Zhao, Tengfei Li, Zirui Fan, Yue Yang, Juan Shu, Xiaochen Yang, Xifeng Wang, Tianyou Luo, Jiarui Tang, Di Xiong, Zhenyi Wu, Bingxuan Li, Jie Chen, Yue Shan, Chal E. Tomlinson, Ziliang Zhu, Yun Li, Jason L. Stein, Hongtu Zhu

Science · 2023

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Summary

) for heart MRI traits, which shared genetic influences with cardiovascular and brain diseases. Genetic correlations were observed between heart MRI traits and brain-related traits and disorders. Mendelian randomization suggests that heart conditions may causally contribute to brain disorders. Our results advance a multiorgan perspective on human health by revealing heart-brain connections and shared genetic influences.

Source type
Peer-reviewed study
DOI
10.1126/science.abn6598
Catalogue ID
SNmojad6s2-0hzar5
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