Pulse Brain · Growing Health Evidence Index
Tier 4 — Narrative / commentaryPeer-reviewed

The influence of the dietary exposome on oxidative stress in pregnancy complications

Jelmer R. Prins, Mirthe H. Schoots, Jule I. Wessels, Marjo Campmans‐Kuijpers, Gerjan Navis, Harry van Goor, Sarah A. Robertson, Eline M. van der Beek, Luis Sobrevía, Sanne J. Gordijn

Molecular Aspects of Medicine · 2022

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Summary

This comprehensive narrative review synthesises evidence on how the dietary and broader exposome influences oxidative stress pathways implicated in major pregnancy complications including preeclampsia, fetal growth restriction, preterm birth, and gestational diabetes. The authors identify modifiable environmental and lifestyle factors—particularly dietary exposures—that regulate reactive oxygen species generation, and appraise dietary interventions as a low-risk therapeutic strategy to mitigate adverse pregnancy outcomes through oxidative stress reduction.

Regional applicability

The review synthesises evidence of international scope and applicability. Findings on dietary modulation of oxidative stress in pregnancy are relevant to United Kingdom maternity practice and public health guidance, though implementation would require integration with existing antenatal nutrition and preeclampsia prevention protocols.

Key measures

Reactive oxygen species production; dietary intervention effects on oxidative stress markers in pregnancy

Outcomes reported

The review examined endogenous and exogenous exposome factors regulating reactive oxygen species in healthy and complicated pregnancies, and evaluated dietary interventions aimed at reducing oxidative stress to attenuate adverse pregnancy outcomes.

Theme
Nutrition & health
Subject
Maternal, infant & child nutrition
Study type
Narrative Review
Study design
Narrative review
Source type
Peer-reviewed study
Status
Published
Geography
International
System type
Human clinical
DOI
10.1016/j.mam.2022.101098
Catalogue ID
SNmq0elbry-s1o889

Topic tags

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