Summary
This prospective randomised trial examined non-pharmacological management of sarcopenia in 200 COVID-19 patients with prolonged immobilisation. Patients receiving combined high-protein diet therapy (1.2–1.5 g/kg), probiotics, and physical training for two months showed significant improvements in skeletal muscle index and haemoglobin levels compared to physical training alone, with more patients achieving normal muscle mass indices.
Regional applicability
The study was conducted in an unspecified location and addresses acute post-COVID sarcopenia management in the pandemic context. Findings are potentially applicable to United Kingdom clinical settings managing prolonged COVID sequelae, though UK practitioners should consider local dietary guidelines, probiotic evidence standards, and the shifting epidemiology of post-COVID disability.
Key measures
Skeletal muscle index (SMI, kg/m²), serum albumin (g/dL), haemoglobin (g/dL), Short Physical Performance Battery (SPPB) score, number of patients achieving normal SMI
Outcomes reported
The study measured skeletal muscle index (SMI), serum albumin, and haemoglobin levels in sarcopenic COVID-19 patients treated with high-protein diet therapy and probiotics versus control. It assessed changes in muscle mass, nutritional biomarkers, and functional status over two months.
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