Rice bagasse extract-based green synthesis of zinc oxide nanoparticles: characterisation, assessment of anti-skin cancer, antibacterial, and antioxidant properties

Summary

This study describes the green synthesis of zinc oxide nanoparticles using ethanolic extract of rice bagasse as a capping and stabilising agent. The resulting 28 nm particles demonstrated dose-dependent cytotoxicity against skin cancer cells (IC₅₀ 415.46 μg/ml) and exhibited strong antibacterial, antifungal, and antioxidant properties in vitro. The authors propose these nanoparticles as a viable platform for pharmacological and therapeutic applications.

Regional applicability

This laboratory study on nanoparticle synthesis and in vitro bioactivity has limited direct application to United Kingdom farming or food systems. The therapeutic claims require substantial further development (animal and human studies) before any clinical or agronomic application would be considered.

Key measures

ZnO NP size (28 nm), UV–Vis absorption peak (374.23 nm), zeta potential (−27.6 mV), skin cancer IC₅₀ (415.46 μg/ml), antibacterial and antifungal minimum inhibitory concentrations, antioxidant capacity

Outcomes reported

The study synthesised zinc oxide nanoparticles (28 nm average size) using rice bagasse extract and assessed their cytotoxic, antibacterial, antifungal, and antioxidant properties. Skin cancer IC₅₀ was 415.46 μg/ml, with strong activity against Candida albicans, Escherichia coli, and Staphylococcus aureus.

Topic tags