Summary
This experimental study examined how common food matrices and probiotic supplementation influence the bioavailability of curcumin delivered through four different nanoformulations. Fasting and sugar co-ingestion enhanced bioavailability of nanoemulsions and carbon nanotube formulations respectively, whilst regular kibble and milk reduced absorption. Notably, intestinal colonisation with Bifidobacterium lactis Bb-12 reduced curcumin bioavailability, an effect that was attenuated by carbon nanotube and lipid carrier formulations but not nanoemulsions, with in vitro evidence suggesting protective effects against probiotic-mediated degradation.
Regional applicability
These findings are relevant to UK consumers using curcumin supplements or turmeric-enriched foods, particularly those taking probiotic supplements concomitantly. The results suggest that timing of intake relative to meals and probiotic formulations may influence efficacy, informing consumer guidance and supplement recommendations by UK health professionals.
Key measures
Curcumin bioavailability across four formulations (suspended curcumin, nanoemulsions, single-walled carbon nanotubes, nanostructured lipid carriers) under fasting, milk, sugar, regular kibble co-ingestion, and probiotic colonisation conditions
Outcomes reported
The study measured the bioavailability of curcumin across four nanoformulations under different dietary conditions and probiotic colonisation. It quantified how food co-ingestion and Bifidobacterium lactis Bb-12 supplementation altered curcumin absorption and identified protective mechanisms of specific nanoformulation types.
Topic tags
Dig deeper with Pulse AI.
Ask about this record, its theme or its relevance to UK farming and policy. Pulse AI uses selected catalogue evidence and cites the sources it draws on.