Summary
This narrative review synthesises recent evidence for a bidirectional gut-airway microbiome axis, describing how respiratory insults influence gut microbial composition and function, and conversely how gut-derived microbial metabolites and ligands regulate respiratory immunity. The authors discuss implications for asthma, chronic obstructive pulmonary disease, and lung cancer, offering a mechanistic framework for understanding microbiota-mediated communication across these two major mucosal surfaces.
Regional applicability
The review synthesises international evidence on fundamental mechanisms of host-microbe interactions; findings are applicable to United Kingdom clinical practice and respiratory disease management, though specific epidemiological or treatment outcome data would be country-dependent and require complementary studies in UK populations.
Key measures
Mechanisms of gut-airway crosstalk; microorganism-immune interactions; clinical and treatment outcomes in respiratory conditions
Outcomes reported
The review synthesises evidence for bidirectional communication between gut and airway microbiomes, examining how respiratory insults influence gut microbial activity and how gut-derived microbial ligands and metabolites shape respiratory immunity. It addresses implications for clinical outcomes in asthma, chronic obstructive pulmonary disease, and lung cancer.
Topic tags
Dig deeper with Pulse AI.
Ask about this record, its theme or its relevance to UK farming and policy. Pulse AI uses selected catalogue evidence and cites the sources it draws on.