Summary
This systematic review synthesised evidence from six studies examining whether dietary modifications increasing unsaturated fatty acid intake could improve clinical outcomes in three oral autoimmune conditions: oral lichen planus, recurrent aphthous stomatitis, and pemphigus. All included studies reported improvements in clinical parameters and subjective complaints following dietary intervention, suggesting nutritional optimisation may represent a valuable adjunctive therapy component that could reduce reliance on conventional pharmaceuticals.
Regional applicability
The findings are geographically non-specific, being derived from a multi-database international systematic review. UK clinical practitioners managing oral autoimmune diseases may consider these results relevant to developing evidence-informed dietary counselling protocols, though local implementation would require appraisal of individual study quality and applicability to UK patient populations and healthcare contexts.
Key measures
LA-derived oxylipins (9-HODE, 13-HODE), ulcer size (mm), monthly ulcer count, pain (VAS scale), episode duration, quality of life (OHIP-14), healing time, fatty acid composition of plasma phospholipids, Pemphigus Disease Area Index (PDAI), AHEI-2010 diet quality score
Outcomes reported
The systematic review evaluated clinical parameters and subjective complaints in patients with oral lichen planus, recurrent aphthous stomatitis, and pemphigus following dietary modifications increasing unsaturated fatty acid intake. Measured outcomes included ulcer size, monthly ulcer frequency, pain scores, episode duration, quality of life, healing time, and disease severity indices.
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