Summary
This field trial in two Tanzanian districts assessed the efficacy of five trematocide drugs against concurrent Fasciola gigantica and amphistome infections in cattle herds. The findings demonstrate that nitroxynil, oxyclozanide, closantel, and triclabendazole achieved 100% faecal egg count reduction against F. gigantica by day 14, whilst albendazole showed markedly reduced efficacy (49–89% FECR). Oxyclozanide was the sole drug effective against amphistomes, suggesting emerging anthelmintic resistance in the study regions and practical implications for livestock health extension services.
Regional applicability
The United Kingdom has different fluke species (Fasciola hepatica) and lower prevalence of livestock fasciolosis than Tanzania, but the findings on anthelmintic resistance patterns may inform UK surveillance and stewardship programmes, particularly regarding oxyclozanide and albendazole use in sheep and cattle.
Key measures
Faecal egg count reduction (FECR%) at 7, 14, and 28 days post-treatment; efficacy measured against F. gigantica and amphistomes separately
Outcomes reported
The study evaluated the efficacy of five different trematocide drugs (albendazole, nitroxynil, oxyclozanide, closantel, and triclabendazole) against Fasciola gigantica and amphistome infections in cattle using faecal egg count reduction (FECR) tests measured at 7, 14, and 28 days post-treatment.
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