Summary
This narrative review synthesises evidence on how dietary polyphenols modulate epigenetic processes and signalling pathways implicated in sarcopenia, a key aspect of ageing. The authors argue that compounds such as resveratrol and curcumin may reduce inflammaging and oxidative stress whilst enhancing mitochondrial function, thereby preserving muscle health in older adults. The review emphasises integration of polyphenol intake with physical exercise as part of broader geroscience strategies and identifies epigenetic biomarkers as important future research targets.
Regional applicability
The paper is a mechanistic and literature review with no country-specific data; findings on polyphenol biochemistry and sarcopenia prevention are broadly transferable to United Kingdom populations and clinical practice. However, translation to UK dietary recommendations would require population-specific evidence on polyphenol intake levels, food sources, and efficacy in British older adult cohorts.
Key measures
Epigenetic mechanisms (DNA methylation, histone modifications, microRNA regulation); signalling pathways (mTOR, NF-κB, AMPK); muscle mass and strength; oxidative stress markers; inflammatory biomarkers; mitochondrial function
Outcomes reported
The review examined how dietary polyphenols (resveratrol, quercetin, epigallocatechin gallate, curcumin) modulate molecular and epigenetic pathways to preserve muscle mass and strength in older adults. It synthesised evidence on polyphenols' potential in preventing or attenuating sarcopenia through effects on oxidative stress, inflammation, and mitochondrial function.
Topic tags
Dig deeper with Pulse AI.
Ask about this record, its theme or its relevance to UK farming and policy. Pulse AI uses selected catalogue evidence and cites the sources it draws on.