Summary
This narrative review synthesises evidence on chlorogenic acid, a phenolic compound found widely in plant foods, highlighting its anti-inflammatory and antioxidant mechanisms through modulation of pro-inflammatory cytokines and cellular signalling pathways implicated in cardiometabolic and vascular disease. The authors address a key translational challenge—chlorogenic acid's poor bioavailability—by reviewing emerging delivery technologies (liposomes, micelles, nanoparticles) designed to enhance its stability and cellular uptake, positioning it as a candidate for future clinical investigation.
Regional applicability
This is a mechanistic and pharmaceutical review without geographic specificity. The findings on chlorogenic acid chemistry and delivery are universally applicable. UK practitioners may contextualise this within discussions of functional foods and phytochemical interventions, though the clinical evidence base would require UK-specific dietary and outcome data to inform public health recommendations.
Key measures
Anti-inflammatory mediators (TNF-α, IL-1β, IL-6, IL-8, NO, PGE2); signalling pathway modulation (NF-κB, MAPK, Nrf2); bioavailability; delivery system performance (liposomes, micelles, nanoparticles)
Outcomes reported
The review synthesises evidence on chlorogenic acid's anti-inflammatory and antioxidant mechanisms, specifically its modulation of inflammatory mediators (TNF-α, IL-1β, IL-6, IL-8, NO, PGE2) and signalling pathways (NF-κB, MAPK, Nrf2). It evaluates delivery systems designed to overcome low bioavailability and enhance clinical utility.
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