Summary
This comprehensive review synthesises evidence on the dietary antioxidant index (DAI), a metric designed to quantify total antioxidant intake from diet, and its utility in assessing risk for chronic non-communicable diseases and infections. The authors conclude that higher DAI scores are associated with reduced risk of obesity-related metabolic conditions, certain infections and cancers, bone disease, reproductive complications, and mental health disorders. The review acknowledges gaps in the evidence and calls for additional prospective and interventional studies to confirm DAI's predictive value across disease domains.
Regional applicability
The review is international in scope and does not address United Kingdom-specific populations or health policy. Findings would be relevant to UK nutritional epidemiology and dietary guideline development, though application would require validation in UK cohorts and consideration of local food composition databases and dietary patterns.
Key measures
Dietary antioxidant index scores; associations with obesity, diabetes mellitus, hyperuricemia, dyslipidemia, metabolic dysfunction-associated steatotic liver disease, Helicobacter pylori and human papillomavirus infection, gastric cancer, cervical cancer, osteoporosis, miscarriage, infertility, and mental illness
Outcomes reported
The review assessed the performance of the dietary antioxidant index (DAI) in predicting risk for multiple chronic diseases including obesity-related conditions, infectious diseases, cancers, and other conditions. Evidence was synthesised from published studies on associations between DAI scores and disease outcomes.
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