Summary
This experimental study evaluated herbal plant supplementation (Artemisia absinthium and Malva sylvestris, singly and combined) on antioxidant responses and local immune histopathology in lambs experimentally infected with the gastrointestinal nematode Haemonchus contortus. Combined plant supplementation reduced oxidative stress markers and enhanced tissue regeneration, whilst individual plant effects varied: Malva sylvestris alone elevated antioxidant capacity and reduced mast cell infiltration. The findings represent the first report of these specific plant species' impact on local immune responses in parasitised lambs.
Regional applicability
This work has potential relevance to United Kingdom sheep farming, where gastrointestinal nematode parasites are a persistent challenge in grazing systems. However, the study was conducted in a controlled experimental setting; field validation under UK climate and pasture conditions, cost-effectiveness analysis, and integration with existing anthelmintic strategies would be required before practical farm application.
Key measures
Malondialdehyde concentration, total antioxidant capacity, mucus production, mast cell count, plasma cell count, abomasal tissue regeneration frequency
Outcomes reported
The study measured antioxidant parameters (malondialdehyde, total antioxidant capacity) and histopathological changes (mucus production, mast cell and plasma cell numbers, tissue regeneration) in abomasal tissues of lambs infected with Haemonchus contortus and supplemented with Artemisia absinthium and/or Malva sylvestris.
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